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Table 3 Comparisons between TALEs and TALENs

From: Genome editing in cotton: challenges and opportunities

Characteristics

TALE

TALEN

References

Loss-of-function mechanism

Repression of transcription

Frame shift DNA mutation

Shamshirgaran et al. (2022)

Transgenes

TALE-KRAB

TALEN

Wani et al. (2022)

Guiding sequence

DBD

DBD

Singh et al. (2022)

Required sequence information

Annotated TSS

Transcriptome

Anugraha et al. (2022)

Off-target space

Window around TSS

Genome; requires FokI dimerization

Chaudhuri et al. (2022)

Transcript variants

Only variants from the same TSS

All variants via conserved region

Li et al. (2022b